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Taxol Glossary Here are terms and acronyms used in this article that may not be familiar to many readers:

(Right: Samples of some of the many different analogs produced by Taxolog, Inc. and Holton's FSU Lab, awaiting testing.

Taxol Glossary

Here are terms and acronyms used in this article that may not be familiar to many readers:

10-deacetylbaccatin III (10-DAB): This is the "heart" of the Taxol molecule. It is a large molecule itself found in abundance in the needles of the English yew. (10-dee-ah-SEE-tull-bah-COT-ten three)

analog: a spin-off, or derivative, compound

bioassay: a routine lab test to determine biological activity, conducted in cell cultures, live animals or both

Camptotheca acuminata: Latin name for the Chinese "happy tree" (camp-toe-THEE-ka ah-cue-mi-NA-ta)

camptothecin: cancer-fighting compound discovered by Monroe Wall, co-discoverer of Taxol (camp-toe-THEE-kin)

CRADA: Cooperative Research and Development Agreement, a mechanism for transferring development of a government-owned product to private enterprise

Cremophor EL: a commercial product used as a solvent for Taxol in cancer treatment

FDA: The U.S. Food and Drug Administration

metal alkoxide process: a key chemical technique developed by FSU scientists that made mass production of artificially made Taxol possible

microtubules: microscopic, tube-like structures manufactured by cells; crucial to cell-division and thus growth

NCI: The U.S. National Cancer Institute, a division of the National Institutes of Health

NMR spectrometer: an instrument that uses the technique of nuclear magnetic resonance (NMR) to analyze chemical composition of various substances

petri dish: a small glass or plastic dish with a cover used for growing bacteria or cell cultures in a laboratory

semisynthesis: the process of artificially making a compound in the lab by using part of the end product as the primary starting raw material

taxane: a class of chemicals whose molecular structure includes the primary constituents of Taxol

Taxus brevifolia: Latin name for the Pacific yew tree, the original source of Taxol (TAX-us breh-vi-FOL-ee-ah)

technology transfer: the process of transferring the discoveries of academic scientists and scholars to the marketplace

tubulin: the key protein building block of microtubules (see above)

USDA: The U.S. Department of Agriculture



SIDE BAR
STORIES
Out of the Park
Holton Process
Beyond Taxolog
Glossary